# C OCULOGICA PUBLICATIONS KEY TAKE-AWAYS

# Metrics of concussion-related vision disorders among children and adolescents with persisting post-concussive symptoms using an objective eye tracking device

Master, C., Scheiman, M., Podolak, O., Grady, M., Howell, D (2025)

A Early detectionfconcussion-related visual dysfunction (CRVD) through a comprehensive exam by a binocular ecalsouasraiRovalab.OX BOX score was significantly higher in individuals with CRVD $( \\mathsf { A U C } = 0 . 7 6 3 7 )$ . Each 1-point increase in the BOX score raised the odds of CRVD by $15 %$ , highlighting its potential as a useful screening tool. The EyeBOX may thus be uat overall outcomes.

# Eye tracking for classification of concussion in adults and pediatrics

Samadani U., Spinner R.J., Dynkowski G., Kirelik S., Schaaf T. Wall S.P., Huang P. (2022)

Eye tracking has the potential to serve as an objectivegold-standard for detection ofneurophysiologic intened ue poulati" wascludedomee njecti r nA label whih was that al ubje h nen dy normal population, the number of True Negatives would have increased along with specificity.

# Objective infrared eye tracking aids in the identification of concussionrelated vision disorders in adolescents with persistent postconcussive symptoms

Master, C. Rogers, T. Podolak, O., Howell D., Grady, MF, Scheiman, M. (2022)

uuv identiy concussion-elatedvisin disordersn adolescents with persistent post-concussion symptoms wit a area under the ROC curve $( \\mathsf { A U C } ) = 0 . 7 3$ . The BOX score alone had an $\\mathsf { A U C } = 0 . 6 7$ $\\scriptstyle ( \\mathsf { p } < 0 . 0 1 )$ . This implies that VVE an Bo Scoremeasuredifferent aspect concussion.Thee esults suggest that anbjective yeraci variable may be a valuable addition to the current concussion battery.

# Eye tracking metric differences among uninjured adolescents and those with acute or persistent post-concussion symptoms

Jain, D., Arbogast, K.B., McDonald, C.C., Podolak, O.E., Margulies, S.S., Metzger, K.B., Howell, D.R., Scheiman, M.M., Master, C.L. (2022)

Obtiveyetrackingtechnolog capable quickly entiyingvision and pupillaristurbancee concussion, augmenting traditional clinical concussion assessments. The eye tracking metrics may enhance existing clinical practice for monitoring recovery in a heterogeneous adolescent concussion population.

# Objective eye tracking metrics of vision and autonomic dysfunction distinguish adolescents with acute concussion and those with persistent post-concussion systems from uninjured controls

Jain, D., Arbogast, K.B., McDonald, C.C., Podolak, O.E., Margulies, S.S., Metzger, K.B., Howell, D.R., Scheiman, M.M., Master, C.L. (2022)

Octiveeetrackigtechnology canidentiyvision an pupillary disturbancs after concussion.The y tol co concussion population and may identify sex-specific differences in autonomic dysfunction.

# The association between baseline eye tracking performance and concussion assessments in high school football players

Oldham, J.R., Master, C.L., Walker, G.A., Meehan, W.P. 3rd, Howell, D.R. (2021)

Eye tracking was not significantlyassociated with the commonly used clinical concussion assessments. These uls haecacvblemylablinhe battery.

# Impaired eye tracking is associated with symptom severity but not dynamic postural control in adolescents following concussion

Oldham, J.R., Meehan W.P. 3rd, Howell, D.R. (2020)

The concussion group with abnormal eye tracking results had worse overall total symptom severity andhigher alu healthy controls.

# Objective eye tracking deficits following concussion for youth seen in a sport medicine setting

Howell, D.R., Brillant, A.N., Storey, E.P., Podolak, O.E., Meehan, W.P. 3rd, Master, C.L. (2018)

Visal nctiportanpoenthe osconcusion valationanentiyineso injury may allow for earlier specialist referral and intervention.

# Eye tracking as a biomarker for concussion in children

Bin Zahid, A., Hubbard, M.E., Lockyer, J., Podolak, O., Dammavalam, V.M., Grady, M., Nance, M., Scheiman, M., Samadani, U., Master, C.L. (2018)

Eye tracking correlates with concussion symptoms and detected convergence and accommodative alsa ovasivinthediagnosi concussion.erackngeliablydetectconvergenceanaccomati abnormalities as well asother typesofoculomotordysfunction associated wit concussion in the pedi aeailci diagnosis of concussion that does not require pre-injury data for interpretation.

# Reliability of objective eye-tracking measures among healthy adolescent athletes

Howell, D.R., Brilliant, A.N., Master, C.L., Meehan, W.P. (2018)

Automated and quantitative eye movement and conjugacy metrics provide relatively stable measurements grohealy youtheTulsial ackimemay to other visual examination techniques when monitoring concussion recovery across time.

# Elevated intracranial pressure and reversible eye-tracking changes detected while viewing a film clip

Kolecki, R., Dammavalam, V., Bin Zahid, A., Hubbard, M., Choudhry, O., Reyes, M., Han B. Wang, T. Papas, P.V., Adam, A., North, E. Gilberston, D.T. Kondziolka, D., Hang, J.H., Huang, P.P., Samadani, U. (2017)

These results suggest that eye tracking may be used as a noninvasive, automatable means to quantitate the eaCh malfunction, pseudotumor cerebri, concussion, and prevention of second-impact syndrome.

# A new tool for monitoring brain function: eye tracking goes beyond assessing attention to measuring central nervous system physiology

Samadani, U. (2015)

Twmanucriptdescinovelgoritm orracknghat may euseul rncussin, herr raBh0 asseses brain function rather than appearanceor electrical activity and thus represents a relatively newer modality rssessment central nervous system integrity.The dfference between the wo papers publihed a trackngRather than assessing what smeone chooes to look t, the tracking measures how welthe yes can move.

# Concussion

# Will eye tracking change the way we diagnose and classify concussion and structural brain injury?

Samadani, U. (2015)

oylal pressure or disruption of neurologic pathways.

# Eye tracking detects disconjugate eye movements associated with structural traumatic brain injury and concussion

Samadani, U. Ritlop, R. Reyes, M. Nehrbass, E., Li, M., Lam, E. Schneir, J, Shimunov, D., Sava, M., Kolecki, R., Burris, R., Altomare, L., Mehmood, T., Smith, T., Huang, J.H., McStay, C., Todd, S.R., Qian, M., Kondziolka, D., Wall, S., Huang, P. (2015)

Establimenerackinjectivmeasranablstgprotectivevic . helet) wehepeui. Itn potentally nablorm desnakiardnn baseline activity or sport play. Concussion may be the first of several neurological disorders or which eye tracking will be the preferred diagnostic.

# Detection of third and sixth cranial nerve palsies with a novel method for eye tracking while watching a short film clip

# Concussion

Samadani, U., Farooq, S., Ritlop, R., Warren, F., Reyes, M., Lamm, E., Alex, A., Nehrbrass, E., Kolecki, R., Jureller, M., Schneider, J., Chen, A., Shi, C., Mendhiratta, N., Huang, J.H., Qian, M., Kwak, R., Mikheev, A., Rusinek, H., George, A., Fergus, R., Kondziolka, D., Huang, P.P., Smith, T. (2015)

Results suggest that eye tracking may be used as a noninvasive, automatable means to quantitate the lo ll ca asmenhun malfuncton edotumor re ncssion, preenti en-mpac snm

# Eye movement conjugacy while watching a video reveals greater vertical than horizontal disconjugacy in human subjects

Samadani, U. Ciddi, D., Chen, A., Lamm, E., Ritlop, R., Alex, A., Warren F., Huang, P., Smith T. (2014)

Normal control subjects haveeemovements that are more conjugate when viewing a video playing in aall aprrslrnninehnal ervl pa y. Sincugaazayulial pathologyeoi wehavevopa for automatable assessment and monitoring of patients with neurologic dysfunction.